LRP1 and Alzheimer disease: Suppression of hepatic LRP1 has been shown to decrease Aβ uptake by the liver (Tamaki et al., 2006), while its upregulation by the root extract Withania somnifera (WS) was shown to decrease plasma- and brain-Aβ levels and improve cognitive function in aged AD mice (Sehgal et al., 2012).