Our work examined APP and Aβ in total brain of wild-type mice, while other studies used transgenic AD mice (APP23/PS45 mice) where human APP and PSE1 are overexpressed (Huang et al., 2018) or studied APP increase in specific regions of the brain (cerebellum, hippocampus, and striatum), and not total brain homogenates. The gene discussed is IPO5; the disease is Alzheimer disease.