NRG4 or ErbB4-induced downregulation led to insulin resistance and hepatic steatosis in high-fat diet-fed mice (Wang et al., 2014; Zeng et al., 2018; Wang et al., 2019a; Zhu et al., 2020), supporting the importance of NRG4-ErbB4 signalling in the prevention of obesity-associated metabolic disturbances. The gene discussed is ERBB4; the disease is Insulin resistance.