Increased levels of NRG4 in situations of altered glucose tolerance or early diabetes (Kang et al., 2016; Chen et al., 2017a; Kurek Eken et al., 2018; Wang et al., 2019c; Kocak et al., 2019), but decreased in those patients with advanced diabetes (as reflects increased microalbuminuria) (Kocak et al., 2020), suggest that NRG4 levels might depend on the evolution and stage of development of diabetes. This evidence concerns the gene NRG4 and diabetes mellitus.