VEGFA and inborn error of immunity: As shown in Figures 6A,B, time-correlated genes were polarized in the metabolism pathways (inositol phosphate metabolism, nucleotide metabolism, pyrimidine metabolism, and nicotinate/nicotinamide metabolism), the pathways related to cell proliferation (cell cycle, DNA replication), immune-related pathways (Fc epsilon RI signaling pathway, B cell receptor signaling pathway, T cell receptor signaling pathway, chemokine signaling pathway, Fc gamma R-mediated phagocytosis, and primary immunodeficiency), and other signaling (Rap1 signaling pathway and VEGF signaling pathway).