As NT-proBNP, it has also been reported that the presence of B-lines in HF patients is an independent prognostic factor (Coiro et al., 2015; Gargani et al., 2015; Gustafsson et al., 2015; Aras and Teerlink, 2016; Platz et al., 2016; Rivas-Lasarte et al., 2020; Domingo et al., 2021) although no study to date has analysed its prognostic value when added to the most used contemporary risk scores. The gene discussed is NPPB; the disease is hydrops fetalis.