Recently, Nanog expression has been reported in human neoplasms, including germ cell tumors (Ezeh et al., 2005; Hart et al., 2005; Hoei-Hansen et al., 2005; Santagata et al., 2007), breast carcinomas (Ezeh et al., 2005), osteosarcoma (Gibbs et al., 2005), and HCC (Ma et al., 2008). This evidence concerns the gene NANOG and hepatocellular carcinoma.