Whole genome and exome analysis demonstrated that TP53, CTNNB1, and chromatin modulators, including ARID1A and ARID2, are the most frequently mutated coding genes in HCC (Shibata and Aburatani, 2014; Totoki et al., 2014; Fujimoto et al., 2016). Here, CTNNB1 is linked to hepatocellular carcinoma.