Induction of HCV proteins or the infection of HCC cells with HCVcc inhibits histone H4 methylation/acetylation and histone H2AX phosphorylation and inhibited DNA damage repair, indicating that HCV-induced overexpression of PP2Ac promotes hepatocarcinogenesis via dysregulation of epigenetic histone modifications (Duong et al., 2010). Here, H2AX is linked to hepatocellular carcinoma.