Induction of HCV proteins or the infection of HCC cells with HCV cell culture (HCVcc) suppresses histone H4 methylation/acetylation and histone H2AX phosphorylation for HCC development, indicating that HCV-induced overexpression of PP2Ac are associated with HCC via deregulation of epigenetic histone modifications (Duong et al., 2010). This evidence concerns the gene PPP2CA and infection.