CD4 and lymphopenia: Past studies have shown that >80% of the patients suffered from lymphopenia, and its severity aligns with the intensity of COVID-19 infection.7,27 Several cases of herpes virus infections in patients with positive SARS-CoV-2 demonstrated a decrease in the T lymphocyte subpopulations and, specifically, that in CD4+ and CD8+T lymphocytes before the onset of HZ.28,29 SARS-CoV-2 reduces CD4+T cells more severely than CD8+T cells.