The pathogenesis of arterial hypertension is based on dysregulation of the endothelium, VSMCs dysfunction, nitric oxide (NO) synthesis, increased oxidative stress, impaired angiogenesis, activation of the sympathetic nervous system, and changes in the activity of the renin-angiotensin-aldosterone system (RAAS) [[9], [10], [11]]. The gene discussed is REN; the disease is Hypertension.