Moreover, rs11614913 C allele in miR-196a-2 could reduce H2O2-induced apoptosis in melanocytes, indicating that the rs11614913 C allele in miR-196a-2 may decrease the risk of vitiligo and protect against oxidative effects on human melanocytes through regulating its target gene TYRP1. Another study showed that miR-196a-2 rs11614913 polymorphisms may regulate the expression levels of tyrosinase (Cui et al., 2015), which can control the production of melanin and influence the susceptibility of vitiligo. Here, TYRP1 is linked to vitiligo.