TYR and vitiligo: Moreover, rs11614913 C allele in miR-196a-2 could reduce H2O2-induced apoptosis in melanocytes, indicating that the rs11614913 C allele in miR-196a-2 may decrease the risk of vitiligo and protect against oxidative effects on human melanocytes through regulating its target gene TYRP1. Another study showed that miR-196a-2 rs11614913 polymorphisms may regulate the expression levels of tyrosinase (Cui et al., 2015), which can control the production of melanin and influence the susceptibility of vitiligo.