SIRT3 and myocardial ischemia: SIRT3 is considered a new key actor in CVDs, due to its cardioprotective effects which are reflected mainly in the fact that a loss of SIRT3 expression increases the susceptibility to suffer or worsens the pathological phenotype in cardiac ischemia-reperfusion injury and coronary microvascular dysfunction, thus impairing cardiac recovery (Sun et al., 2018).