MFN2 and obesity due to melanocortin 4 receptor deficiency: On the other side, upregulation of MFN2 attenuates the CH induced by angiotensin II (Yu et al., 2011), and complementarily; in diabetes and obesity, which are conditions correlated with an increased risk of CVDs, MFN2 expression is downregulated, and can be recovered with weight loss and exercise (Bach et al., 2005; Cartoni et al., 2005).