In 2011, Serrano-Pozo et al. classified the neuropathological hallmarks of AD as “positive” lesions including the deposition of amyloid plaques, neurofibrillary tangles containing hyperphosphorylated tau, microglial abnormal activation with astrogliosis, and neuroinflammation, and “negative” lesions comprising the neuronal and synaptic damage or loss. Here, MAPT is linked to Alzheimer disease.