Functional studies have shown that inhibition of ABCE1 (Gao et al., 2020), ASCC3 (Dango et al., 2011), and VCP (Costantini et al., 2021) may inhibit cancer cell growth and survival, whereas inhibition of NEMF/Clbn (Bi et al., 2005) and ZNF598 (Yang and Gupta, 2018) may have opposite effects. The gene discussed is ABCE1; the disease is cancer.