Importantly, many RQC factors such as NEMF, ANKZF1, ZNF598, and Rack1, but not ABCE1 or eRF1, were found deposited at the core of amyloid plaques from AD patient brains (Rimal et al., 2021), a finding that further supports the central role of defective RQC of ribosome collision and stalled translation in AD pathogenesis. Here, ABCE1 is linked to Alzheimer disease.