I-BET726, a novel BET small molecule inhibitor, binds to the hydrophobic cavity of BET family proteins to block the interaction of BRD4 and acetylated histone which downregulates MYCN and BCL2 expression to retard NB cell growth, promote differentiation and apoptosis (Galderisi et al., 1999; Jiang et al., 2011; Wyce et al., 2013). Here, BRD4 is linked to neuroblastoma.