Importantly, p53 inactivation is frequently observed in the NB tumors after relapse, therefore, the combination of MDM2 inhibitor CGM097 and BET inhibitor OTX015 exhibited a synergistic inhibition of NB cell growth by activating p53 and decreasing expression of MYC family proteins (Maser et al., 2020) (Figure 2). The gene discussed is MDM2; the disease is neuroblastoma.