Moreover, JQ1 and CDK inhibitor dinaciclib showed synergistic effect on the induction of cytotoxicity in MYCN amplified NB cells but the combination of AZD5153 and dinaciclib reduced the tumor size in mice models in vivo through increasing the tumor necrosis and lymphocyte infiltration (Wood et al., 2021). The gene discussed is MYCN; the disease is neuroblastoma.