APOE and atherosclerosis: SR-B1 KO mice display distinctively large HDL enriched in apolipoprotein E (ApoE) and UC and an increased incidence of pathologies in critical physiological systems, including high atherosclerosis susceptibility (Rigotti et al., 1997; Rigotti et al., 2003; Hoekstra et al., 2010; Liu et al., 2021).