NPHS1 and congenital nephrotic syndrome, Finnish type: In order to model the CNF using zebrafish, we generated zebrafish nphs1 mutants with CRISPR/Cas9-mediated genome editing and found that these mutants recapitulate the human CNF phenotypes and provides a novel and relevant disease model for in vivo functional studies of nephrin and for the screening of therapeutic agents targeting nephrin deficiency.