Retinal transfection of AAV-expressing CAT and superoxide dismutases 2 (SOD2) prolonged cone photoreceptor survival in mice during retinal degeneration (Xiong et al., 2015), and AAV-CAT also exerts neuroprotective effects on retinal ganglion cells in ischemia-induced retinal injury in rats (Chen and Tang, 2011). The gene discussed is SOD2; the disease is retinal degeneration.