Berberine mediates BNIP3 expression by enhancing the binding of HIF-1α to the BNIP3 promoter, thereby inducing cardiomyocyte proliferation and autophagosome formation to inhibit cardiomyocyte apoptosis and myocardial ischemia/reperfusion injury (Zhu et al., 2020). Here, HIF1A is linked to myocardial ischemia.