Overexpression of eNOS and iNOS (but not nNOS) in liver cancer tissues contributes to increase NO levels in liver cancer patients, which in turn inhibit autophagy by disrupting the binding of BECN1/VPS34 and promoting apoptosis by increasing the B cell lymphoma-2 (BCL-2)/BECN1 interaction in liver cancer cells (Zhang et al., 2019a). This evidence concerns the gene PIK3C3 and liver cancer.