AKT1 and Alzheimer disease: In addition, alborixin (an ionophore) also exhibits strong neuroprotective effects, inhibiting the PI3K/AKT pathway to induce autophagy, upregulating the levels of BECN1, ATG5, and ATG7 to increase lysosomal activity, and significantly reducing the levels of Aβ in microglia and primary neurons, thus preventing or slowing the progression of AD (Wani et al., 2019).