EGR1 and posterior cortical atrophy: Lu et al. (2021) identified the upregulated circCSPP1 in PCA tissues and proved that high levels of circCSPP1 significantly enhanced the autophagy process as well as the proliferative and metastatic capability of PCA cells. miR-520h could be bound by circCSPP1 and affect the EGR1 expression to mediate the abovementioned effects. Yu et al. (2022) identified highly expressed circCEMIP in PCA cells and tissues, which functioned as a miR-1248 sponge to regulate downstream TM9SF4 protein expression level, further inhibiting mTOR phosphorylation and facilitating the autophagy process.