Li et al. (2020a) learned about the abnormal expression of circ_0054537 in RCC and confirmed that repression of circ_0054537 observably suppressed the proliferation, metastasis, autophagy, and glycolysis of RCC cells, which was proved to be mediated by the miR-640/NPTX2 axis (Pei et al., 2021). Yan et al. (2019) identified upregulated circ_0035483 in RCC cells, which was proved to reinforce the autophagy of RCC cells through modulating the miR-335/CCNB1 axis. This evidence concerns the gene NPTX2 and renal cell carcinoma.