Yuan et al. (2022) identified downregulated circ_0072309 in GBM and proved that over-expressed circ_0072309 upregulated RNF144B protein levels via sponging miR-100, leading to a decrease in ubiquitin-mediated p53 degradation, which enhanced autophagic cell death and TMZ sensitivity of GBM cells. This evidence concerns the gene TP53 and glioblastoma.