These two types of T-cells, CD8, and CD4 play a major role in the killing of beta-cells in specific Antigens recognized by these immune cells including many -cell antigens, including proinsulin and proinsulin, insulinoma antigen, IGRP, GAD65, as well as islet amyloid polypeptide (Gonzalez-Duque et al., 2018). Here, INS is linked to pancreatic insulinoma.