IL6 and Behcet disease: IL-6 also influences several physiological processes involved in BD, that may also indirectly affect prefrontal cortical volumes and functioning, including the regulation of hypothalamic-pituitary-adrenal axis, noradrenergic, serotoninergic and glutamatergic transmission, kinase signaling, and oxidative stress (Müller and Schwarz, 2007; Meng et al., 2020; Mastorakos et al., 1994; Anderson et al., 2014).