Two MAP2 phosphorylation events in the projection domain (pS233 and pS1031) have been reported to be decreased (case:control ratio = 0.82–0.83) in DLPFC of individuals with major depression, though these changes did not remain significant after controlling for false discovery rate (Martins-de-Souza et al., 2012). This evidence concerns the gene MAP2 and major depressive disorder.