MAP2 and Cerebral ischemia: As previously alluded to (see Section “Neuronal death—marker or effector?”), cerebral ischemia/hypoxia have previously been shown to reduce numbers of MAP2-IR-positive neurons in human neocortex and hippocampus; however, although causes of death associated with cerebral hypoxia or ischemia were more common in our schizophrenia subjects, they also did not explain the differences in MAP2-IR (DeGiosio et al., 2019).