MAPT and Alzheimer disease: Interestingly, this residue is homologous to S396 in Tau- a residue which is associated with AD and regulates Tau localization as well as LTD (Bramblett et al., 1993; Mondragón-Rodríguez et al., 2014; Regan et al., 2015; Xia et al., 2015; Wesseling et al., 2020).