Mutant Tau mouse lines such as rTg4150 can replicate key features of tauopathy including neuron loss and memory impairments (Denk and Wade-Martins, 2009). Phosphomimicry of Tau can lead to learning and memory deficits in Drosophila and mice (Beharry et al., 2013; Di et al., 2016). This evidence concerns the gene MAPT and tauopathy.