For example, PLPPR2 expression is deregulated in colorectal cancer patient samples and cells (Boonsongserm et al., 2019), while in breast cancer samples, PLPPR2 shows high frequency of an aa substitution at T278 (PLPPR2 T278S), potentially worsening breast cancer outcome (Li et al., 2015). This evidence concerns the gene PLPPR2 and colorectal cancer.