Cx26 model mice that present late-onset progressive deafness mainly include p.V37I homozygous mutant mice, Cx26± mice, and Gjb2loxP/loxP; Rosa26cre ER mice which received injection with tamoxifen at P5, P8, and later (Zhu et al., 2015; Chen et al., 2016; Lin et al., 2019). Here, GJB2 is linked to deafness.