Considering that OHCs in the high-frequency region require more energy, it could not only explain that Cx26 defect model mice with delayed progressive hearing loss that usually start to hearing impairment at the high frequencies but also explain that Cx26-related delayed hearing loss has noise susceptibility and age-related characteristics (Fetoni et al., 2018; Lin et al., 2019). Here, GJB2 is linked to hearing loss disorder.