Wang et al. (2020) found the LCN2 levels in the brain were increased significantly at 1 h in WT mice after tMCAO compared to LCN2–/– mice (Bokhari et al., 2014). LCN2 levels peaked at 23 h and then decreased by 48–72 h. In 1996, Elnelhoum et al. analyzed LCN2 levels in plasma from 156 patients between one day and three days after stroke (Elneihoum et al., 1996). Here, LCN2 is linked to Stroke.