LCN2 and Stroke: Currently, several measures can be considered to reduce LCN2 mediated brain damage after stroke: (1) targeting LCN2 gene expression with gene editing or RNA interfering technologies; (2) inhibiting LCN2 protein elevation with specific antibodies; (3) binding LCN2 receptors with antagonists; (4) blocking LCN2 brain injury-related pathways; (5) activating LCN2 neuronal protection-related pathways.