LCN2 and ischemic stroke: Chen X. et al. (2020) found that LCN2 and LCN2R in rat hippocampal neurons increased significantly after injury and induced neuronal apoptosis in a mitochondrion-related manner. Xing et al. (2014) concluded that released LCN2 from injured neurons would send out a “help-me” signal, thereby promoting glial cells to polarize to pro-recovery phenotypes that ultimately lead to beneficial results after ischemic stroke.