To fully elaborate on this topic, published research from PubMed in clinical and basic studies and review or meta-analysis were included, using the following terms: “Lipocalin 2,” “brain injury,” “receptor,” “stroke,” “intracerebral hemorrhage (ICH),” “intraventricular hemorrhage (IVH),” and “subarachnoid hemorrhage (SAH).” The inclusion criteria state that selected articles must be related to this topic and published in peer-reviewed journals. This evidence concerns the gene LCN2 and Stroke.