CACNA1A and familial or sporadic hemiplegic migraine: While little is known about the interactions of α1ACT and their impact on SCA6, CACNA1A pathogenic variants have been associated with various neurological disorders including Developmental and Epileptic Encephalopathy (DEE), episodic ataxia type 2 (EA2), familial hemiplegic migraine type 1 (FHM1), and SCA6 (Pietrobon, 2010).