CASP3 and cerebellar ataxia: SCA1 is another adult-onset, progressive, inherited ataxia that presents with cognitive impairment, difficulty with speaking and swallowing, and eventual chronic lung infections and respiratory failure (Todi et al., 2007; Ju et al., 2014; Pérez Ortiz and Orr, 2018; Tejwani and Lim, 2020).