Other genetic risk factors on the ALS-FTD disease spectrum include mutations in DNA/RNA-binding proteins TAR DNA-binding protein 43 (TARDBP, TDP-43) and fused in sarcoma (FUS), both of which are predominantly nuclear proteins but have recently been found to have a function at the synapse (Ling, 2018). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.