The findings illustrated that a vast majority of genes have substantial variations in expression, in which NOP2, TET3, DNMT3B, DNMT3A, DNMT1, ALYREF are considerably up-modulated in tumor tissues, whereas NSUN3, NSUN6, TRDMT1, TET2, and ALKBH1 are remarkably down-modulated in tumor samples. The gene discussed is TET2; the disease is neoplasm.