In this randomized, double-blind controlled trial, consuming a jelly drink containing polyphenol-rich roselle extract and passion fruit juice plus pulp concentrate (RP jelly drink) once daily for 8 weeks, clearly demonstrated a significant reduction in LDL-C and TG levels when compared to either baseline measurements or jelly drink placebo in Thai adults with dyslipidemia, whereas the changes in fasting plasma glucose, total cholesterol, HDL-C, MCP-1, interleukin-6, and interleukin-10 indicated no significant difference between the RP jelly drink and the placebo group. The gene discussed is IL6; the disease is metabolic syndrome.