Our study reported that calcitriol significantly decreased ROT-induced motor impairment, neuroinflammation, and autophagy dysfunction in the midbrain of the rat model of PD presumably due to calcitriol-upregulated Sirt1 expression that could in turn with subsequent stimulation of autophagy and inhibition of NF-κB. The gene discussed is NFKB1; the disease is Parkinson disease.