AGT and Cerebral ischemia: Hosomi et al. (2005) demonstrated that intravenous infusion of Ang II increases cerebral edema and mortality after cerebral ischemia-reperfusion injury (Hosomi et al., 2005). These results suggest that the accumulation of Ang II leads to endothelial dysfunction, which could produce severe cerebrovascular manifestations such as intracerebral hemorrhage (ICH), ischemia stroke (IS), and hemorrhagic stroke (HS) (it is calculated that the combined prevalence of cerebrovascular diseases in COVID-19 patients is ranging between 0.5 and 5%) (Tsivgoulis et al., 2020).