AGT and hypertensive disorder: For instance, due to the decreased ACE2 hydrolytic activity, Ang II increases over Ang-(1-7), therefore overstimulating the AT1R and over activating the classical axis of RAS, which can eventually translate into hypertension, thrombosis, lung edema, fibrosis, and hyper−inflammatory reactions (Pucci et al., 2021; Zhang et al., 2021).