The lack of Ang II processing by ACE2 favors the binding of this peptide to AT1R, which can cause a local pro-inflammatory state that activates neuronal programmed cell death and the consequent dopaminergic neuronal loss, which could have some consequences as cognitive problems in patients recovered from COVID-19 as is shown in Figure 2 (Khezri and Ghasemnejad-Berenji, 2021). The gene discussed is ACE2; the disease is COVID-19.