AGT and endothelial dysfunction: In that sense, the binding of Ang II to AT1R in the brain promotes the activation of pro-inflammatory and pro-oxidant signaling pathways leading to endothelial dysfunction, thrombo-inflammatory processes, and reduction of cerebral irrigation, resulting in cerebrovascular complications (Tsivgoulis et al., 2020), which could partially explain the appearance of some of the neurological symptoms associated with COVID-19.