Collectively, these results imply that miR-205 may be downregulated, which may contribute to the potential pathogenic elevation of LRRK2 protein in the brains of sporadic PD patients, while miR-205 overexpression may offer a useful therapeutic approach to suppress the abnormal upregulation of LRRK2 protein in PD (Cho et al., 2013). Here, LRRK2 is linked to Parkinson disease.