INS and type 2 diabetes mellitus: With regard to the contribution of AAs to insulin appearance/disappearance (kAA model parameter), model analysis of the average data from the literature yielded 0.0247 (confidence interval, CI: 0.0168 – 0.0325) and -0.0048 (CI: -0.0281 – 0.0185) μU·ml-1/(μmol·l-1·min), for CNT and T2D, respectively.