Thyroid cancers developed in Brafthyr–V600E, Brafthyr–V600E,Atg5thyr–KO/KO, and Brafthyr–V600E,MieapKO/KO mice are similar in terms of the degree of cell proliferation and differentiated status, but tumor sizes and ROS levels indicated by 53BP1 foci were the highest in Brafthyr–V600E,MieapKO/KO mice. Here, TP53BP1 is linked to thyroid gland carcinoma.