To investigate the role of MIEAP and ATG5 in thyroid carcinogenesis, we prepared Brafthyr–V600E, MieapKO/KO, Atg5thyr–KO/KO, Brafthyr–V600E,MieapKO/KO, and Brafthyr–V600E,Atg5thyr–KO/KO mice. The gene discussed is SPATA18; the disease is thyroid gland disorder.