LGR5 and colorectal cancer: (30) showed accelerated tumor formation with enhanced cell proliferation and reduced apoptosis in a mouse model of colorectal cancers with Lgr5–creER,Apcflox/flox,PolgAmut/mut mice (PolgAmut/mut mice are a model of accelerated mtDNA mutagenesis) compared with Lgr5–creER,Apcflox/flox mice.