These results demonstrate that both ATG5 and MIEAP are indeed tumor suppressors and are consistent with previous studies showing an acceleration of development of lung tumors in lox–stop–lox–KrasG12D,Atg5flox/flox or 7flox/flox and lox–stop–lox–BrafV600E,Atg7flox/flox mice intranasally delivered with adenovirus expressing Cre (26–28) and of colon cancers in ApcMin,MieapKO/KO mice (18). Here, SPATA18 is linked to malignant colon neoplasm.