ATG5 and neoplasm: However, no tumor development in the thyroids of MieapKO/KO and Atg5thyr–KO/KO mice in this study and also in the lungs or colons in the above studies (adenovirus expressing Cre–treated Atg5/7flox/flox and MieapKO/KO mice) suggests that MIEAP or ATG5/7 KO alone is not sufficient for tumor initiation in the thyroids, lungs, and colons.