HMBS and neoplasm: Among them, the higher expressions of 11 overlapped molecules (UPs; survival-related genes), including SPG20, PFN2, SET, CBX1, HISTIH1B, DSC3, ENO1, NONO, HISTIH4H, ACTA2 and PGK showed a better prognosis, which suggested their protective effects; while the higher expressions of 22 overlapped molecules (UPs; survival-related genes), including PRKCKBP, DDX5, ATP11A, EPB2, RPS2, ITGB1, TANK, GPRC5A, TRIM47, MVP, RNF213, SAP18, HM13, ICAM1, SLC16A4, LRSAM1, TM9SF3, CALD1, SYNPO, CLTB, CA1 and GJA5 demonstrated a worse prognosis, which suggested their tumor-promoting effects.