Patients with surgical remission were older at diagnosis of acromegaly (49 years ±11 vs. 39 years ±12, p<0.001], had lower fasting GH [5.5 μg/L (IQR: 3.1-16.0) vs. 19.9 μg/L (IQR: 9.8-42.4), p=0.007], lower IGF-1 (3.1 xULN ± 1.2 vs. 3.7 xULN ± 1.2) and lower PRL concentrations at diagnosis [11.1 ng/mL (IQR: 9.2-15.0) vs. 19.7 ng/mL (IQR: 7.8-38.8), p=0.026]. The gene discussed is PRL; the disease is acromegaly.