In silico analysis has predicted that these mutations may lead to the formation of new binding sites for transcription factors (e.g. SOX4) or their loss (PRDM14; HMX2; MTE; DREAM) with a consecutive reduction in the expression levels of MKRN3 associated phenotypically with CPP (26, 28). This evidence concerns the gene MKRN3 and central precocious puberty.