In 2018, two groups identified in patients with CPP a small deletion (c.-150_-147delTCAG) in the promoter region of the MKRN3 gene (26) and a single nucleotide substitution in the 5’ UTR(c.-81C>T) (27) both associated with a reduced promoter activity of the gene in transfected cells (Figure 1). Here, MKRN3 is linked to central precocious puberty.