(24) reported that the previously well-known mutations for adrenocortical adenoma (GNAS, CTNNB1, PRKAR1A, PRKACA, PDE11A, PDE8B, KCNJ5, CACNA1D) (31) and PCC (RET, VHL, NF1, SDHA, SDHB, SDHC, SDHD, SDHAF2, TMEM127, MAX, EGLN1(PHD2), EPAS1(HIF2A), KIF1B, MET, FH, and H-RAS) (32) were not detected in their MCMT. The gene discussed is PDE8B; the disease is adrenal cortex adenoma.