As shown in Figure 1, the decrease in utilization of glucose owing to insulin resistance promotes fatty acid β-oxidation to supply 90%-100% of energy associated with the translocation of cluster of differentiation 36 (CD36), a fatty acid transporter, into the sarcolemma and enhanced LCFA uptake in the cardiomyocyte, meanwhile leads to the lipotoxic cardiomyopathy in diabetes (14–16). Here, INS is linked to diabetes mellitus.