NLRP3 and heart failure: Additionally, NLRP3 inflammasome, assembled by NLRP3, caspase-1, and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), has been considered as another inflammatory participant in the ventricular remodeling and dysfunction of cardiac disease such as acute myocardial infarction, DCM and heart failure (117–119).