Additionally, NLRP3 inflammasome, assembled by NLRP3, caspase-1, and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), has been considered as another inflammatory participant in the ventricular remodeling and dysfunction of cardiac disease such as acute myocardial infarction, DCM and heart failure (117–119). The gene discussed is NLRP3; the disease is acute myocardial infarction.