The constituents of ESZWD in CHF-HKYd rats mainly include alkaloids, saponins, terpenoids, and tanshinones, among which salsolinol, aconitine, paeoniflorin, and miltrione have suitable pharmacokinetic profiles and are negatively correlated with NT-proBNP, they are equipped with potential characteristics as pharmacodynamic substances for ESZWD in treatment of CHF-HKYd. The gene discussed is NPPB; the disease is congestive heart failure.