Our previous study (28) appeared that the activities of CYP1A2, CYP2B1, CYP2C6, CYP2C11, and CYP3A1 in CHF rats were significantly reduced, as we know, CYP450 mediated 90% of drug metabolism (29), the change of metabolic enzyme activity caused by CHF-HKYd may be one of the reasons for the chemical compounds inconsistencies. This evidence concerns the gene CYP1A2 and congestive heart failure.