In this study, the effects of C. zeylanicum hydroethanolic extract on the latencies of the first minimal clonic seizure (MCS) and the first generalized tonic-clonic seizure (GTCS), as well as the levels of NO, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and thiol in the hippocampus and cortex tissues after seizures induced by PTZ in mice were investigated. Here, CAT is linked to Bilateral tonic-clonic seizure.