We also found important pathways related to HCC, such as DNA damage checkpoint, T cell receptor signaling pathway, ErbB signaling pathway, Notch signaling pathway, VEGFA-VEGFR2 pathway, programmed cell death, tyrosine kinases receptor signaling, and adaptive immune system (Figure 6A, Supplementary Figure 6A-B). This evidence concerns the gene KDR and hepatocellular carcinoma.