Among the GO, KEGG and Reactome result data of GSEA in HCC, the frequent signaling pathways influenced by CCDC6 were enriched in the cell cycle process and gene transcription terms including histone acetyltransferase complex, mitotic sister chromatid segregation, cell cycle checkpoint, Ubiquitin-mediated proteolysis, and adherens junctions. The gene discussed is CCDC6; the disease is hepatocellular carcinoma.