However, endurance exercise significantly increased the mRNA level of IL-12, significantly decreased the mRNA level of Arg-1, and it had a trend of decreasing the mRNA level of CD206 in the spleen of lung cancer mice (Figure S1A, B), suggesting that endurance exercise promotes the conversion of spleen tissue macrophages from M2 to M1 type. This evidence concerns the gene ARG1 and lung carcinoma.