We found significant correlation between HK2 and the autophagy-related gene set, including mechanistic target of rapamycin kinase (mTOR), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), pyruvate dehydrogenase kinase 1 (PDK1), AKT serine/threonine kinase 1 (AKT1), TBC1 domain family member 7 (TBC1D7), protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), Ras homolog MTORC1 binding (RHEB), mTOR associated protein LST8 homolog (mLST8), ribosomal protein S6 kinase B1 (RPS6KB1) in breast cancer patients through the GEPIA2 database (Figure 6B). The gene discussed is PIK3CA; the disease is breast carcinoma.