HK2 and breast cancer: We found significant correlation between HK2 and the autophagy-related gene set, including mechanistic target of rapamycin kinase (mTOR), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), pyruvate dehydrogenase kinase 1 (PDK1), AKT serine/threonine kinase 1 (AKT1), TBC1 domain family member 7 (TBC1D7), protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), Ras homolog MTORC1 binding (RHEB), mTOR associated protein LST8 homolog (mLST8), ribosomal protein S6 kinase B1 (RPS6KB1) in breast cancer patients through the GEPIA2 database (Figure 6B).