These findings are consistent with in vivo neuroimaging evidence for reduced synaptic density, as measured by reduced binding of positron emission tomography (PET) radioligands targeting synaptic vesicle glycoprotein 2A (SV2A) in schizophrenia (12, 13), reduced dendritic spines (14), and a meta-analysis confirming decreased expression of synaptic proteins in post-mortem brain tissue from individuals with schizophrenia (15). Here, SV2A is linked to schizophrenia.