ALT at baseline (aOR 2.3, 95% CI 1.4–3.8), younger age (aOR 1.0, 95% CI 0.9–1.0), and obesity at baseline (aOR 3.2, 95% CI 1.2–8.0) were significantly associated with elevated ALT after 5 years of tenofovir treatment (Table 2). The gene discussed is GPT; the disease is Obesity.