A study found that the level of S100A12 in the feces of infants with suspected NEC was higher than that of infants without gastrointestinal diseases; the sensitivity, specificity, and positive and negative predictive values of fecal S100A12 for NEC detection were 70%, 68%, 37%, and 89%, respectively (35). Here, S100A12 is linked to gastrointestinal disease.