CDX2 and neoplasm: Among the various features, non-pedunculated gross type, high histological grade, LVI, myxoid-type tumor bud stroma, high tumor bud count, TB mitosis, and loss of CDX2 expression were independent predictors of LNM, whereas LNM, histology grade, LVI, TBC, stroma type, and TB mitosis were independent predictors of local recurrence in patients with pT1 CRC.