VWF and esophageal varices: Hence, most of the non-invasive predictors described above were also studied in evaluating esophagogastric varices, like ICG-r15 could identify patients at high risk for esophageal varices and have similar performance with HVPG (AUROC, 0.859 vs. 0.816) (59); SHAPE could screen high-risk variceal bleeding with AUROC of 0.95 (78); other indices as PLT, AST, ALT, VWF-AG, LSM, and SSM were also discussed (124–127).