The injury of liver parenchyma was the feature of liver fibrosis, related liver function indices including single platelet count (PLT), aspartate aminotransferase to alanine aminotransferase (AAR) ratio, aspartate aminotransferase to platelet count ratio index (APRI), fibrosis index based on 4 factors (FIB-4 consists of PLT, AST, ALT, and age), glutamyl transpeptidase to platelet (GPR), King’s score (consists of Age, AST, INR, and PLT), Lok score (consists of PLT, AST, ALT, and INR), and the CSPH risk score (consists of ALB, INR, and ALT) have been validated to evaluate PH. The gene discussed is ALB; the disease is Hepatic fibrosis.