Inflammation was an initiating and accompanying factor of liver fibrosis, and the study (41) in 90 cirrhotic patients proved the significant correlation between PH and inflammatory biomarkers, including IL-1b, IL-1Ra, Fas-R, and VCAM-1, and construct a paradigm based on TNFb, HSP-70, alcohol use, and Child-Pugh Class B, which could screen HVPG < 12 mmHg with the accuracy of 86%, however, performed poorly in diagnosing HVPG ≥ 12 mmHg with AUROC of 0.767. Here, VCAM1 is linked to Hepatic fibrosis.