Concerning the connection between drug reactions with eosinophilia and systemic symptoms (DRESS) to treatment with IL-1- or IL-6-inhibitor and the development of pulmonary manifestations, Saper et al. found a significant enrichment for HLA-DRB1*15 in a cohort of patients with Still's disease (both sJIA and AOSD) with lung involvement (33). This evidence concerns the gene IL6 and adult-onset Still disease.