USP7, also known as herpesvirus-associated ubiquitin-specific protease, is involved in modulating the stability of several key proteins, including tumor suppressors (Li et al., 2002; Song et al., 2008), transcription factors (van der Horst et al., 2006), epigenetic modulators (Du et al., 2010; Wang et al., 2016a; Wang et al., 2016b), proteins involved in DNA damage response (Zhu et al., 2015; Su et al., 2018) and regulators of immune response (van Loosdregt et al., 2013). The gene discussed is USP7; the disease is neoplasm.