Studies have shown the role of USP7 in the regulation of numerous cancer-related pathways and proven that high levels of USP7 are directly correlated with tumor progression in numerous cancers including breast cancer (Wang et al., 2016b), ovarian cancer (Qin et al., 2016), prostate cancer (Song et al., 2008), cervical cancer (Su et al., 2018) and colorectal cancer (An et al., 2017), among others. The gene discussed is USP7; the disease is colorectal cancer.