FLT3 and neoplasm: Compounds 10 and 11 (Figure 9) were the most potent and selective FLT3 inhibitors (FLT3 IC50 of 1.1 and 1.6 nM, respectively) of the series with sub nanomolar IC50 in counteracting the MV4-11 cell lines proliferation and excellent pharmacokinetic properties and efficacy in a human tumor xenograft model in mice (Patel et al., 2009).